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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Nifedipine and Diallyl Trisulfide

Research Papers that Mention the Interaction

Compared to the control groups, higher C(max) and AUC(0-24 h) were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS , whereas those for intravenous nifedipine were little changed.
In conclusion, DATS increased the oral exposure of nifedipine in rats likely by the modification of intestinal metabolism of nifedipine, indicating that combined use of DATS or DATS-containing supplement with nifedipine may require caution because high plasma concentrations may lead to an undesired toxicity of this agent.
Practical Application: Patients suffering from cardiovascular disease should take caution in combined use of DATS or DATS-rich garlic supplement with nifedipine because long-term treatment of DATS could lead high plasma concentrations of nifedipine.
The oral bioavailabilities of nifedipine were remarkably enhanced via the concomitant use of DATS.
Journal of food science  •  2011  |  View Paper