Possible Interaction: Nifedipine and Calcium Supplement

“ Nifedipine blunted the pressor response to salt loading > 50% (delta diastolic BP [high-low salt vs placebo] = 5 +/- 2 vs 14 +/- 2 mmHg, P < 0.05) and reversed salt-induced ionic changes, lowering Cai and elevating Mgi and pHi.”

“Combined … of calcium and nifedipine in responders (29 cases, group A) in a single-blind, placebo-controlled manner showed a further substantial decrease (9.6/3.2 mmHg) in pressure compared with pressures during placebo administration in both short- as well as long-term administration in group B patients.”

“It is … proven that nifedipine reduces Ca-dependent vascular smooth muscle tone by direct interference with transmembrane Ca supply and thereby counteracts every kind of contractile tension development of the vascular wall: the higher the wall tension, the easier relaxation in induced by a given concentration of the compound.”

“Moreover, intraperitoneal injections of L-type Ca2+ channel blocker nifedipine after stress resulted in a significantly lower rate for developing stress-related cognitive and morphological changes seen in PTPN5 knockdown rats.”

“ Nifedipine , an L-type Ca2+ channel blocker, reduced Ca2+ -wave amplitude and FPD in hiPSC-CMs, and led to parallel effects of decreased ventricular contractility and shortened QT interval in isolated hearts.”

“These Ca2+ signals were inhibited by nifedipine , Cd2+, U73122, xestospongin C and ryanodine, suggesting contributions from both Ca2+ influx through voltage dependent L-type Ca2+ channels plus Ca2+ release from intracellular stores mediated by IP3 receptors and ryanodine receptors.”

“Both of these effects were largely blocked by the L-type Ca2+ channel antagonist nifedipine.”

“Co-treatment of the E1A.NR3 cells with Rec-1 in the presence of nifedipine , a L-type Ca2+ channel blocker, significantly suppressed the increase of Ca2+.”

“ Nifedipine , an inhibitor of calcium uptake throughl-type calcium channels, inhibited the action of NGF on both 3T3-Trk cells and 3T3-p75 cells, indicating that both p140 trk and p75NGFR receptors are linked to nifedipine-sensitive l-type calcium channels.”

“The 1alpha,25(OH)2D3-induced Ca2+ influx was completely blocked by pre-treatment with nifedipine (2 x 10(-5)M), an L-type Ca2+ channel antagonist.”