Possible Interaction: Nifedipine and Adrenocorticotropic Hormone

“ Nifedipine … ACTH response to combined naloxone/AVP stimulation by 43% (AUC: 1,576.4 +/- 417.9 vs. 897.0 +/- 186.2; p < 0.05), but it … the sum of the individual responses (897.0 +/- 186.2 vs. 576.1 +/- 106.1, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)”

“Short‐term administration of nifedipine , a calcium channel antagonist, had no effect on basal or peak cortisol levels but reduced the incremental cortisol response to corticotropin.”

“Dihydropyridine, nifedipine , a specific L-type Ca(2+) channel blocker, inhibited significantly the CRH-induced ACTH and corticosterone response in rats exposed to 3 days crowding stress but not in rats under basal conditions.”

“Whereas NIF also inhibited PMA-induced ACTH secretion in AtT-20 cells, it did not in sheep AP cells.”

“In contrast, CRH-, KCl-, and MTX-stimulated ACTH secretion were significantly inhibited in static monolayer culture when cells were pretreated with the voltage-dependent calcium channel blocker, nifedipine (NIF, 1 microM, 15 min), confirming the requirement for the influx of extracellular calcium.”

“Two inhibitors of Ca2+ channels nifedipine and PY108-068) inhibit both the production of steroids by unstimulated bovine cells and the stimulation produced by three agents ( ACTH , (Bu)2 cAMP, and K+).”

“ ACTH inhibition also was additive with inhibition by the calcium channel blocker, nifedipine.”

“TPA mediated ACTH release was dependent on extracellular calcium and inhibited by nifedipine , to a maximum of 35%.”

“ Nifedipine (both 10(-5) and 10(-4) M) inhibited CRF stimulated ACTH release but only to a maximum of 30%.”

“ Nifedipine inhibited ACTH release induced by synthetic rat CRF-41 in two systems.”

“ Nifedipine inhibited CRF-41-induced ACTH release and the inhibitory effect of nifedipine on CRF-41-induced ACTH release was accompanied by parallel decrease of cyclic AMP levels in pituitary halves.”