Possible Interaction: Nicotine and Yohimbine

“ Yohimbine stimulated nicotine intake and increased PR breakpoints and numbers of infusions received in both male and female adolescent rats.”

“We also found that rats with higher demand for nicotine were more sensitive to pretreatment with yohimbine which resulted in increased responding for nicotine during the dose-effect tests.”

“We found that AT‐1001 dose‐dependently reduced yohimbine stress‐induced reinstatement of nicotine seeking.”

“On the other hand, intra-BLA injection of different doses of α2-adrenoceptor antagonist, yohimbine (1, 3 and 5 μg/rat) in combination with an ineffective dose of nicotine (0.3 mg/kg) decreased %OAT and %OAE, suggesting a potentiative effect of the antagonist on nicotine response.”

“The antinociceptive action of (−)-nicotine was antagonized by mecamylamine and yohimbine but not by naloxone and atropine.”

“ Yohimbine pretreatment prevented both the increase in juxtamucosal pH gradient depth and the protective effect of nicotine.”

“However, an alpha(2)-adrenoceptor antagonist, yohimbine (0.5 and 1 mg/kg), appeared to reverse the nicotine response, but did not show interaction with nicotine's effect.”

“Mecamylamine and hexamethonium but not atropine, scopolamine, yohimbine , phenoxybenzamine, tolazoline, propranolol, practolol, chlorpromazine, haloperidol, antazoline and methysergide abolished the convulsions evoked by nicotine.”