Possible Interaction: Nicotine and Vitamin D

“In the present study, in vivo VC was induced in rats by administering vitamin D3 plus nicotine.”

“Further, vascular calcification was induced by vitamin D3 plus nicotine in rats and isolated thoracic aortas, calcium concentration was assessed in rat aortic rings in vitro.”

“Rat vascular calcification model was constructed by administration of vitamin D3 plus nicotine.”

“Conclusions: Flushing dose of vitamin D3 and nicotine can induce the change of pathology and function of the kidney.”

“In this study, we investigated the protective effects of Ang-(1-7) on VC in an in vivo rat VC model induced by vitamin D3 plus nicotine.”

“… nicotine had significantly … of 25-hydroxyvitamin D than controls [20.8+/-1.4 ng/ml for the low dose group and 20.7+/-1.0 ng/ ml for … high dose group versus 27.6+/-1.3 ng/ml for the control group (mean+/-S.E.M.), P<0.01].”

“Cardiac function was investigated in conscious normotensive rats in which increased aortic stiffness was produced as a result of vascular calcium overload after treatment with vitamin D3 plus nicotine (VDN rats, n = 16; controls, n = 17).”

“Increased aortic stiffness was produced by calcium overload of elastic arteries after vitamin D3 plus nicotine treatment.”

“ Vitamin D3 plus nicotine treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two.”

“of S‐12968‐(−) produced no change in total peripheral resistance, and in rats pretreated with vitamin D3 and nicotine , cardiac output fell.”

“1 Treatment of young rats with vitamin D3 plus nicotine produced 31 and 4 fold increases in the calcium content of the aorta and the mesenteric arterial bed, respectively.”