Possible Interaction: Nicotine and Vitamin C

“Bone morphogenetic protein‐2 (BMP‐2) expression and the calcium depositions decreased at 100 and 1,000 ng/ml nicotine , while the addition of Vitamin C reversed the down regulation.”

“This study was to evaluate the in vitro effects of nicotine on human bone marrow stromal cells and whether Vitamin C supplementation show the antagonism action to high concentration nicotine.”

“ Vitamin C could antagonize the inhibitory effect of higher concentration of nicotine partly.”

“Supplementation with ascorbic acid could be a simple approach to block possible NNN formation in nicotine patch users.”

“Conclusions The present findings indicate that vitamin C was unable to prevent the renal vasoconstriction, but it prevented the fall in cGMP provoked by nicotine in non-smokers.”

“The results of this study indicate that dietary levels of AA are inversely correlated to urinary excretion of nicotine metabolites and may be due to suppressed: (1) nicotine intake by smokers who smoked fewer cigarettes or inhale less deeply, (2) nicotine metabolism, or (3) both.”

“ Nicotine exposure significantly reduced forced expiratory flows, but supplementation of mothers with 250 mg vitamin C per day prevented the effects of nicotine on expiratory flows.”

“We now report that vitamin C supplementation can prevent some of the effects of maternal nicotine exposure on pulmonary function of offspring.”

“In a primate model, vitamin C blocked some of the in-utero effects of nicotine on lung development and offspring pulmonary function.”

“ Nicotine added under the conditions of this experiment decreased the ascorbic acid of whole blood about 24 to 31 per cent.”

“ Nicotine lowers the concentration of ascorbic acid in the rat adrenal.”

“However, vitamin C administered with nicotine decreased the metabolism of nicotine and, thus, increased nicotine excretion.”

“The presence of necrosis in the nicotine plus vitamin C group was significantly lower on day 21 (P = .005).”

“Both vitamins C and E prevented the shortening of arteriolar platelet aggregation time significantly (p<0.001) when applied with nicotine but not alone.”