Possible Interaction: Nicotine and Thiamine

“Furthermore, expression of the important thiamin-metabolizing enzyme, thiamin pyrophosphokinase (TPKase), was significantly reduced in PAC of mice exposed to nicotine.”

“Similarly, chronic exposure of cultured human PAC to nicotine (0.5 μM, 48 h) significantly inhibited thiamin uptake, which was also associated with a decrease in expression of THTR-1 and THTR-2 proteins and mRNAs.”

“The results showed that chronic exposure of mice to nicotine significantly inhibits thiamin uptake in murine PAC, and that this inhibition is associated with a marked decrease in expression of THTR-1 and THTR-2 at the protein, mRNA and hnRNAs level.”

“ Thiamine , in very small concentrations (1:10000), inhibits the vasoconstrictor action of nicotine in the frog vessels.”

“Yamamoto and coworkers have reported the pharmacological studies on nicotine from the standpoints of toxicology and metabolism (18-24) and have demonstrated that thia mine was an interesting antagonist to nicotine , because of the inhibition to nicotine induced convulsions and death, antidiuretic action and ganglion stimulating action etc. (”

“The fact that thiamine possessed an antagonistic action on nicotine toxicity was firstly pointed out by Unna et al. in 1944 (13) and the present author found also that thiamine inhibited selectively the action of nicotine as well as nornicotine in vitro.”

“The present experiment was aimed to elucidate the antagonistic mechanism between thiamine and nicotine , and also to investigate the structure-activity relationship of various thiamine related compounds.”

“Cocaine, its pharmacologically active metabolites, norcocaine benzoylnorecgonine, benzoylecgonine and other central nervous system stimulants e.g. dextrococaine, nicotine , caffeine and p-hydroxy norephedrine formed molecular complexes with thiamine.”