Possible Interaction: Nicotine and Serine

“Pre-incubation with growth hormone (0.2 microgram/ml) decreased the transport of serine, whereas nicotine (0.5 microgram/ml) decreased both serine and phenylalanine uptake.”

“Furthermore, nicotine exposure promoted autophosphorylation of Ca2+/calmodulin‐dependent kinase II (CaMKII) and serine 831 phosphorylation of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) subunit GluA1.”

“Although nicotine had no effect on total cardiac glycogen synthase kinase-3β (GSK3β) protein expression, it significantly increased the phosphorylation of GSK3β at serine 9 residue in the heart.”

“Based on their previous work [12–15], the authors illustrated nicely that chronic nicotine exposure increased the ischaemia-reperfusion-induced AKI-dependent serine 36 phosphorylation (S36A) and ischaemia-reperfusion-induced AKIdependent renal expression of p66shc.”

“Administration by microdialysis of 10 mM nicotine , resulting in a nicotine concentration of 0.134 μmol/g in the hippocampus, increased the extracellular levels of aspartic acid, glutamic acid, and serine by 26–60%.”

“It was further shown that the a-carbons of glycine’ and glycolate and the P-carbon of serine were also incorporated into the N-methyl group of nicotine to a relatively large extent, although to a lesser extent than was formaldehyde (l-3).”