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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nicotine
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Pretreatment of RES (50, 100, and 250 μM), OXY (50, 100, and 250 μM), and RES+OXY (50 and 100 μM) inhibited cytotoxicity and ROS production caused by nicotine in a dose-dependent manner.”
Smilax China root extract detoxifies nicotine by reducing reactive oxygen species and inducing CYP2A6.“ Resveratrol and Ad-SIRT1 inhibited nicotine and LPS-mediated protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), p38, ERK, JNK, MAPK and nuclear factor-kappa B (NF-κB) activation.”
“However, when resveratrol (1×10(-8) μM or 1×10(-7) μM) was added concurrently to the embryos exposed to nicotine , all the parameters in above improved conspicuously.”
Resveratrol prevents nicotine-induced teratogenesis in cultured mouse embryos.“MitoTEMPO and resveratrol both significantly attenuated the adverse cardiac remodeling induced by nicotine , as well as the aggravation of postischemic ventricular dysfunction.”
Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction“In this study we have examined the inhibitory effects of resveratrol in nicotine induced proliferation of pancreatic cancer cells.”
“Mitogen activated protein kinase (MAPK) analysis revealed up-regulation of p-ERK expression by nicotine (p<0.05) that was suppressed significantly by resveratrol (p<0.05).”
“We conclude that resveratrol acts as an effective antioxidant in reversing the nicotine induced pancreatic cancer cell proliferation.”
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