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Possible Interaction: Nicotine and Procaine

supplement:

Procaine

Research Papers that Mention the Interaction

The nicotine response was antagonized by hexamethonium, procaine , and pronethalol.
Gut  •  1969  |  View Paper
Procaine at this concentration also inhibited respiratory hyperventilation caused by nicotine (10−4 g·ml−1=6.2·10−4 mMol·ml−1) applied to the caudal and rostral areas.
Pflügers Archiv  •  2004  |  View Paper
The administration of procaine into either the fourth ventricles or nodular cerebellum blocked the behavioral responses of either vasopressin or nicotine given into the fourth ventricles.
Pharmacology Biochemistry and Behavior  •  1986  |  View Paper
Procaine (3.67 mM), high K + (80 mM) and d -tubocurarine (25 µM) but not acetylcholine (ACh 2.3 µM) blocked contractions and increased 45 Ca retention induced by nicotine , whereas nicotine blocked contractions elicited by ACh but not those obtained with high K + .
The Journal of pharmacology and experimental therapeutics  •  1972  |  View Paper
Procaine , 3 x 10-6g/ml, elicited an 81 and a 64% inhibition of the primary and secondary contractile response to nicotine , in 10 experiments.
The Journal of pharmacy and pharmacology  •  1971  |  View Paper
The biogenic amines, pentolinium, nicotine and arecoline antagonized nerve block induced by cocaine, procaine , chlorpromazine, imipramine, strychnine, LSD, etc.
International journal of neuropharmacology  •  1969  |  View Paper
Residual Ca45 uptake is inhibited at pH 7.40 when procaine is added to solutions containing 10 mM nicotine.
The nicotine contracture is augmented by procaine at pH 8.40 and inhibited by procaine at pH 7.40.
The Journal of pharmacology and experimental therapeutics  •  1968  |  View Paper
However, when experiments were made with preparations which exhibited tone in the absence of histamine, 50pg/ml of procaine blocked the relaxations to nicotine or to acetylcholine.
The local anaesthetic agents, procaine (10pg/ml) or cocaine (1-20 pg/ml), abolished the relaxations caused by acetylcholine and greatly reduced those produced by nicotine.
The Journal of pharmacy and pharmacology  •  1966  |  View Paper