Possible Interaction: Nicotine and Procaine

“The nicotine response was antagonized by hexamethonium, procaine , and pronethalol.”

“ Procaine at this concentration also inhibited respiratory hyperventilation caused by nicotine (10−4 g·ml−1=6.2·10−4 mMol·ml−1) applied to the caudal and rostral areas.”

“The administration of procaine into either the fourth ventricles or nodular cerebellum blocked the behavioral responses of either vasopressin or nicotine given into the fourth ventricles.”

“ Procaine (3.67 mM), high K + (80 mM) and d -tubocurarine (25 µM) but not acetylcholine (ACh 2.3 µM) blocked contractions and increased 45 Ca retention induced by nicotine , whereas nicotine blocked contractions elicited by ACh but not those obtained with high K + .”

“ Procaine , 3 x 10-6g/ml, elicited an 81 and a 64% inhibition of the primary and secondary contractile response to nicotine , in 10 experiments.”

“The biogenic amines, pentolinium, nicotine and arecoline antagonized nerve block induced by cocaine, procaine , chlorpromazine, imipramine, strychnine, LSD, etc.”

“Residual Ca45 uptake is inhibited at pH 7.40 when procaine is added to solutions containing 10 mM nicotine.”

“The nicotine contracture is augmented by procaine at pH 8.40 and inhibited by procaine at pH 7.40.”

“However, when experiments were made with preparations which exhibited tone in the absence of histamine, 50pg/ml of procaine blocked the relaxations to nicotine or to acetylcholine.”

“The local anaesthetic agents, procaine (10pg/ml) or cocaine (1-20 pg/ml), abolished the relaxations caused by acetylcholine and greatly reduced those produced by nicotine.”