Possible Interaction: Nicotine and Oxiracetam

“Combinations of oxiracetam and nicotine improved passive avoidance more than either drug given separately.”

“In the active avoidance task, a combination of oxiracetam with the lower dose of nicotine exerted improving effects never observed with nicotine alone, even at higher doses.”

“Perhaps, oxiracetam and nicotine activate different types of cholinergic mechanisms, but it cannot be excluded that other neurotransmitters, particularly catecholamines, may be involved in the avoidance facilitating effects produced by nicotine and by combinations of the two drugs.”