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“These results demonstrate differences between chronic treatment with (+)- and (–)-nicotine in physiological responses such as body temperature and biochemical changes such as changes in nAChRs and NMDA receptor binding, although a cross-tolerance between the two enantiomers in behaviour and body temperature is also observed.”
“At 6 mM concentrations, (-)-nicotine was found to be approximately 28- and 19-fold more potent than (+)- , and (+/-)-nicotine (racemic), respectively.”