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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nicotine
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“Administration by microdialysis of 10 mM nicotine , resulting in a nicotine concentration of 0.134 μmol/g in the hippocampus, increased the extracellular levels of aspartic acid, glutamic acid , and serine by 26–60%.”
“Subcutaneous administration of nicotine at a dose of 6 μmol/kg caused a 57% increase in the extracellular level of glutamic acid.”
Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat“The fact that kynurenic acid almost completely prevented the effects of nicotine, and nicotine at this concentration produced a 6-fold increase of glutamic acid release , suggests that the effect of nicotine is mainly mediated via glutamic acid release.”
“The nicotinic agonists, nicotine , cytisine and epibatidine, elicit dose-dependent increases in spinal release of Asp and Glu.”
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