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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nicorandil
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Furthermore, the present results suggest that besides these two mechanisms, a third ODQ‐ and GLI‐insensitive mechanism, possibly involving Ca2+ channel blockade, also participates in the relaxant effects of NIC in KCl‐induced contractions.”
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta“Consequently, nicorandil reduces the concentrations of free Ca in the myoplasm, due to acceleration of the Ca pump at the sarcolemma, and may prevent the phosphorylation of myosin through phosphorylation of myosin light chain kinase.”
“These results suggest that the negative inotropic action of nicorandil is caused by inhibition of Ca influx and intracellular mobilization of Ca.”
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