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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Nicorandil and Calcium Supplement

Research Papers that Mention the Interaction

Furthermore, the present results suggest that besides these two mechanisms, a third ODQ‐ and GLI‐insensitive mechanism, possibly involving Ca2+ channel blockade, also participates in the relaxant effects of NIC in KCl‐induced contractions.
British journal of pharmacology  •  1999  |  View Paper
Consequently, nicorandil reduces the concentrations of free Ca in the myoplasm, due to acceleration of the Ca pump at the sarcolemma, and may prevent the phosphorylation of myosin through phosphorylation of myosin light chain kinase.
Journal of cardiovascular pharmacology  •  1987  |  View Paper
These results suggest that the negative inotropic action of nicorandil is caused by inhibition of Ca influx and intracellular mobilization of Ca.
Journal of cardiovascular pharmacology  •  1987  |  View Paper