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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nicardipine
supplement:
Potassium
Research Papers that Mention the Interaction
“These results suggest that nicardipine added to cold potassium cardioplegic solution offers additional protection for the myocardium during ischemia and postischemic reperfusion in pediatric cardiac surgery.”
Clinical trial of nicardipine cardioplegia in pediatric cardiac surgery.“ Nicardipine , a dihydropyridine derivative, added either before or after potassium‐induced depolarization, reduces the resultant elevation in cytosolic calcium level both in control and in pertussis toxin‐treated cells.”
Dihydropyridine Modulation of Voltage‐Activated Calcium Channels in PC12 Cells: Effect of Pertussis Toxin Pretreatment“ Nicardipine and diltiazem in concentrations of 100 μmol l−1 reduced the potassium‐induced contraction to 33.0 ± 9.0% and 53.8 ± 6.7% of control respectively (n = 6, P < 0.05).”
“The treatment with 30 microM nicardipine for 14 min at 6 degrees C completely inhibited a potassium contracture by 190 mEq/l potassium ion for 1.5 h after the removal of nicardipine despite the retention of normal resting potentials.”
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