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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Nicardipine and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

GBE administration resulted in a significant decrease in maximal nicardipine plasma concentration (Cmax) and the 23-hour area under the curve (AUC0-23).
GBE significantly increased hepatic P-450 content and reduced the hypotensive effect of nicardipine.
Thus, it is suggested that GBE attenuated the therapeutic potency of nicardipine , probably secondary to increased hepatic drug metabolism.
In vivo  •  2003  |  View Paper
The feeding of GBE for 4 weeks significantly reduced the hypotensive effect of nicardipine that was reported to be metabolized by CYP3A2 in rats.
These findings suggest that GBE reduces the therapeutic potency of the Ca2+ channel blocker, nicardipine , via enhancement of cytochrome P-450 expression.
Life sciences  •  2002  |  View Paper