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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nicardipine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In isolated feline papillary muscle, nicardipine produced a dose-dependent calcium antagonistic effect manifested by depressed indexes of contraction and relaxation.”
Effects of nicardipine on myocardial function in vitro and in vivo.“The Ca2+ plateau was partially inhibited by nicardipine and completely abolished by omission of external Ca2+.”
Calcium influx pathways in rat CNS pericytes.“The amplitude but not the periodicity of rhythmic [Ca2+]i transients in both cell types was partially inhibited by nicardipine , an L‐type Ca2+ channel antagonist, suggesting that the rhythmic [Ca2+]i transients reflect membrane potential depolarizations corresponding to both slow waves and triggered Ca2+ spikes.”
“ Nicardipine largely, but omegaCTX less, blocked Ca2+ action potentials or voltage pulse-induced Ca2+ currents at the cell soma, while omegaCTX completely blocked autaptic EPSCs.”
“The percentage of Ca2+ … the cells with nicardipine, … Ca2+ signals except for the transient increase just after the addition of NPS-ACTH and also blocked completely the stimulative effect … 10 nM, the stimulative effect of steroidogenesis was partly suppressed by nicardipine and also by AA-861, a lipoxygenase inhibitor.”
“Both responses were suppressed by nicardipine , an L-type Ca2+ channel blocker, and the voltage dependence of Ca2+ transient was similar to the current-voltage relation of ICa.”
“ Nicardipine (0.3 μm), a blocker of the L‐type Ca2+ channel , attenuated the ACh‐induced tonic, but not phasic, increases in [Ca2+]i and force.”
“Pretreatment with nicardipine prevented the inhibitory effect of exogenous calcium on the testicular CR activity in 3-week-old rats, indicating that the suppressing action of calcium on the enzyme activity was mediated by the entry of extracellular calcium via calcium channels.”
“Differences in calcium antagonistic properties between nifedipine and nicardipine on one side, and terflavoxate on the other, are further demonstrated by the data on binding experiments.”
“ Nicardipine inhibited the effect of maitotoxin on intracellular calcium concentration in a dose‐dependent manner.”
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