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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nicardipine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Nicardipine , an antagonist of voltage-dependent calcium channels, also increased the inhibition of adrenocorticotropic hormone (ACTH)-stimulated secretion by Cd(2+).”
Role of calcium channels in cadmium-induced disruption of cortisol synthesis in rainbow trout (Oncorhynchus mykiss).“The effect of ACTH in pM range on the steroidogenesis was suppressed completely by the treatment with nicardipine and AA-861 at the same time, indicating that the action was mediated by both Ca2+ and the lipoxygenase metabolite(s) but not by cAMP.”
“The most typical signs (stretchings, yawnings, penile erections, excessive grooming) of … behavioral syndrome induced in rats by the in-tracerebroventricular administration of ACTH — (1-24) (4 μg/rat) were dose-dependently antagonized … the intraperitoneal injection of the selective Ca++ channel inhibitor, nicardipine (dose range: 0.1–1 mg/kg).”
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