Possible Interaction: Niacin and Vitamin E

“The aim of the present study … to investigate whether the addition of vitamin E … NA could improve metabolic control and the residual beta-cell function, as measured by C-peptide secretion, in … and adolescents with recent onset type 1 diabetes; patients were followed-up for 2 years after diagnosis.”

“The updated DVs may lead to a … vitamins (vitamin A, thiamin, riboflavin, niacin , vitamin B-6, vitamin B-12, biotin, and pantothenic acid) and 6 minerals (zinc, selenium, copper, chromium, … required per serving is affected by chemical structure (i.e., form) (natural vitamin E compared with synthetic vitamin E …).”

“Especially vitamin E in combination with other vitamins like vitamin C, vitamin B1, B2, B6, B12, niacin , folic acid, pantothenic acid and selenium, was significantly associated with lower CRP levels.”

“Combination of tocopherol with nicotinamide as adjuvants to conventional insulin therapy promoted normalization of lipid peroxidation and AED, improving beta-cell function.”

“ Tocopherol plus nicotinic acid resulted in normalization of the blood coagulation process, favoured activation of fibrinolysis and improvement of the microcirculatory bed.”

“Prior 10-day administration of tocopherol and nicotinamide to 45 patients caused a decrease in the severity of diastolic abnormalities in those in whom the latter had been abnormal.”

“Single administration of nicotinamide in doses of 250, 500 and 1000 mg/kg and alpha-tocopherol in a dose of 100 mg/kg exerted a pronounced antiepileptic effect under the conditions of over kindling.”

“Pyrocatecol, thymol, … (PCMB) and alpha-tocopherol exhibited strong inhibition, aniline, N-monomethylaniline, aminopyrine, benzphetamine, SKF … exhibited moderate inhibition, and phenol, benzoic acid, acetanilide and nicotinamide exhibited less or no inhibition at the concentrations lower than 1000 micron … as Hg+, Hg2+, Co2+, Cu2+, Mn2+ and U6+ inhibited lipid peroxidation strongly.”