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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Theophylline
Research Papers that Mention the Interaction
“In concentrations where nicotinic acid almost completely blocked the lipolytic actions of noradrenaline or theophylline , nicotinic acid also blocked the increasing action of the drugs on the cyclic AMP level.”
“ Nicotinic acid blocked or reduced the submaximally lipolytic effect of both noradrenaline and theophylline ; the effect of theophylline being most sensitive to nicotinic acid inhibition.”
Inhibition of cyclic AMP formation and lipolysis in rat adipose tissue by nicotinic acid.“ Nicotinic acid (0.04-0.4 mM) antagonized the stimulation of lipolysis caused by adenosine deaminase (0.5 U/ml) or by theophylline (0.5 mM) and the potentiation of norepinephrine effect due to adenosine deaminase.”
Influence of prostacyclin on the antilipolytic effect of nicotinic acid in rat fat cells: a comparison with adenosine deaminase and theophylline.“The latter drugs were equally sensitive to the inhibitory effect of tiadenol, while nicotinic acid reduced the action of theophylline more than the effect of the catecholamine.”
“The apparent Km value for NAD was estimated to be 0.2mM. The enzyme activity was effectively inhibited by nicotinamide (Ki = 65 microM) benzamide (6 microM), 3-aminobenzamide (10 microM), theophylline (35 microM) and thymidine (50 microM).”
“ Theophylline , thymidine, nicotinamide, and some of its analogues blocked the enzymatic activity, while nicotinic acid was ineffective.”
“Cyclonicate, like nicotinic acid , reduced the lipolytic stimulation of theophylline.”
“Liver cyclic AMP doubled 15 min after the administration of nicotinic acid and the effect of theophylline was synergistic.”
“Supplementation of nicotinic acid with theophylline accelerated the glycogen depletion, the onset of hypoglycemia, and the rise in free fatty acids and ketone bodies.”
“It was shown in acute experiments on rats … one hour after an intraperitoneal injection of theophylline (50 mg/kg) there was a decrease in the NAD + NADP content by 19.4%, … tendency to a fall of NAD.H2 + NADP.H2 was expressed, and the total nicotinamide coferment level … reduced.”
“The antilipolytic potencies of insulin and several heterocyclic carboxylic acids nicotinic acid , 3-methylisoxazole-5-carboxylic acid, 3-methyl pyrazole-5-carboxylic acid) revealed marked differ ences after stimulation of lipolysis in isolated fat cells by lipolytic hormones and theophylline.”
“The lipolytic but not the hypocalcémie effect of theophylline was completely inhibited by nicotinic acid.”
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