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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“The release was completely blocked by nicotinic antagonists hexamethonium (100 μmol/l) and mecamylamine (10 μmol/l), and decreased by tetrodotoxin (0.3 μmol/l) and ω-conotoxin (0.1 μmol/l) to 17% and 27%, resp.”
Differences of the electrical and nicotinic receptor stimulation-evoked liberation of norepinephrine from chicken sympathetic neurons in culture: Possible involvement of different pools of the transmitter“2 [3H]‐NA release in response to high concentrations of nicotinic agonists was reduced, but not fully inhibited, by the presence of either tetrodotoxin ( TTX ) or Cd2+ to block voltage‐gated Na+ or Ca2+ channels, respectively.”
“Carbachol and other nicotinic agonists produced marked increases in the frequency of the glutamatergic spontaneous PSCs in the presence of tetrodotoxin , whereas they had little or no effect on current amplitude.”
“ACh and nicotinic agonists applied to the spinal cord produced a barrage of IPSPs that were blocked by TTX and strychnine.”
“The nicotinic agonist-induced enhancement in inhibitory postsynaptic current frequency is blocked by 1.0 microM tetrodotoxin , demonstrating that the effect is mediated through the activation of voltage-dependent sodium channels.”
“Since tetrodotoxin (1 microM) completely antagonized the effect of nicotinic agonists, the site of action of the nicotinic agonists studied was on the somatodendritic nicotinic receptors.”
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