Possible Interaction: Niacin and Taurine

“Moreover, the above effects could be accentuated by the combination of taurine and niacin.”

“In addition, the combined treatment with taurine and niacin inhibits the production of NO by down-regulating the synthesis of BL- induced over-expression of lung iNOS.”

“The activation of transcription factor NF- kB appears to play a central role in the BL- induced lung injury and fibrosis and the antifibrotic effect of the combined treatment with taurine and niacin resides in their ability to suppress the NF - kB activation by preserving the IkB-α protein.”

“Our results suggest that procollagen I and III gene expression in BL-induced lung fibrosis in hamsters is transcriptionally down-regulated by combined treatment with taurine and niacin.”

“The present study was designed to evaluate whether the mechanism for the antifibrotic effect of combined treatment with taurine and niacin involves the down-regulation of BL-induced overexpression of procollagen I and III messenger ribonucleic acid (mRNA) levels in lungs.”

“In the multiple-dose bleomycin-hamster model of pulmonary fibrosis, combined treatment with taurine and niacin blocks the increase in lung collagen deposition.”

“It was concluded from the data presented at this Conference that the combined treatment with taurine and niacin , which offers a multipronged approach, will have great therapeutic potential in the intervention of the development of chemically induced interstitial lung fibrosis in animals and humans.”

“The mechanisms for the protective effect of taurine and niacin are multifaceted.”

“These include the ability of taurine to scavenge HOCl and stabilize the biomembrane; niacin's … replenish the BL-induced depletion of NAD and ATP; and the combined effect of taurine … niacin to suppress all aspects of BL-induced increases in … lung collagen reactivity, a hallmark of interstitial pulmonary fibrosis.”

“Two independent studies showed that taurine and niacin in combination significantly reduced BL-induced increases in bronchoalveolar inflammatory cell counts, protein content, and acid phosphatase activity.”

“The diet supplemented with taurine (2.5%), niacin (2.5%), or taurine (2.5%) + niacin (2.5%) also reduced AD-induced increases in lung collagen accumulation, phospholipids, MDAE and SOD activity.”

“We found that combined treatment with taurine in drinking water (1%) and niacin IP (250 mg/kg) daily, significantly decreased the BL-induced increases in lung MDAE and calcium content, and SOD, PH and poly(ADP-ribose) polymerase activities.”

“Based on the findings of this investigation, it is suggested that combined treatment with taurine and niacin offers the potential for a novel pharmacological approach in the prevention of lung fibrosis in humans.”

“In the present investigation, we have demonstrated that taurine and niacin in combination provide nearly complete protection against BL-induced pulmonary fibrosis.”

“ Niacin (1.2 per cent) caused a greater increase in taurine conjugation than 1.2 per cent taurine.”