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Last Updated: 2 years ago

Possible Interaction: Niacin and Streptozocin

supplement:

Niacin

Research Papers that Mention the Interaction

A non-obese type 2 DM mouse model was established via combined administration of streptozotocin with nicotinamide and exhibited significantly higher plasma glucose concentration and insulin resistance compared with normal controls according to oral glucose tolerance and insulin challenge tests.
Journal of drug targeting  •  2010  |  View Paper
Niacinamide in combination with streptozotocin (a nitrosourea compound) or with heliotrine (a pyrrolizidine alkaloid), produced pancreatic islet tumors.
On the other hand, Niacinamide reduced the renal adenomas produced by streptozotocin ; and intestinal and bladder tumors induced by a preparation of bracken fern.
International journal of toxicology  •  2005  |  View Paper
In addition, nicotinamide has long been known to block the development of diabetes following streptozotocin or alloxan, and to restore proinsulin synthesis to normal following injection of streptozotocin [4].
Journal of autoimmunity  •  1989  |  View Paper
Diabetes was induced by intraperitoneal injection of streptozotocin 65 mg/kg after a dose of nicotinamide 110 mg/kg.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
Diabetes mellitus was induced by single intraperitoneal injections of nicotinamide (120 mg/kg) and streptozotocin (65 mg/kg) administered 15 min apart.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2019  |  View Paper
Although streptozotocin administered after nicotinamide induced slight increases in glucose levels at the beginning of the experiment only, slight, but significant unfavorable changes in the skeletal system were demonstrated.
Nutrients  •  2017  |  View Paper
Diabetes was induced in rats fasting overnight by the intraperitoneal administration of nicotinamide followed by a single dose of STZ.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
A non-obese T2DM rat model induced by co-administration of nicotinamide and streptozotocin was used to evaluate the in vivo efficacy of the nanosystem.
Journal of controlled release : official journal of the Controlled Release Society  •  2016  |  View Paper
High concentration of NAm , 35 mmol/l, causes cytotoxic effect on the viability of pancreatic islet cells and increase of oxidative stress induced by STZ and H2O2.
It was revealed that NAm in concentration of 5 mmol/l not only had cytoprotective effects against STZ and H2O2 but also partially reduced the level of oxidative stress in the investigated cells induced by these compounds.
Ukrains'kyi biokhimichnyi zhurnal  •  2012  |  View Paper
Diabetes was induced by an intraperitoneal injection of nicotinamide followed by streptozotocin.
Nutrition  •  2012  |  View Paper
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