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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Sodium Chloride
Research Papers that Mention the Interaction
“In a second study, chronic dietary administration of nicotinic acid (2.5 and 5.0%) provided significant protection against the development of an elevated blood pressure in rats treated with DOCA salt.”
Effect of chronic dietary treatment with nicotinic acid on the development and maintenance of deoxycorticosterone-acetate-salt-induced hypertension.“In the presence of both GTP and NaCl , prostaglandin E 1 (1 or 10 μM) and nicotinic acid (30 μM) inhibited the enzyme by about 70–80% and epinephrine (300 μM, added in combination with a β-adrenergic blocking agent) by 40–50%.”
“ NaCl generally reduced nicotinic acid salvage for NAD and NADP.”
Pyridine salvage and nicotinic acid conjugate synthesis in leaves of mangrove species.“Using cADPR cycling assay, it was found that NaCl stimulated cADPR production in these cells, which was blocked by inhibition of ADP-ribosyl cyclase with nicotinamide.”
“…,NaCl (100 mM) was demonstrated to stimulate a rapid Ca2+ increase from the endoplasmic reticulum (ER), … a cADPR antagonist, 8-bromo-cADPR (30 µM), an inhibitor of ADP-ribosyl cyclase, nicotinamide (6 mM), the ryanodine receptors blocker, ryanodine (30 µM), … Ca2+ release inhibitor, tetracaine (10 µM) by 70-90%.”
“ Nicotinamide exhibited a salting in effect on the HPMC solutions resulting in an increase in gelation temperatures and cloud points.”
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