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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The PI3K/AKT inhibitor, LY294002, and the mTOR inhibitor, rapamycin , largely neutralized the protective effects of niacin , suggesting that AKT and downstream signaling mTOR/S6 activation are necessary for the niacin-induced protective effects against UV-induced cell death and cell apoptosis.”
Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes“Moreover, the effects of rapamycin on MCs senescence induced by high glucose were also completely blocked by treating cells with niacinamide or siRNA-SIRT1.”
SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
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