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Last Updated: 3 years ago

Possible Interaction: Niacin and Simvastatin



Research Papers that Mention the Interaction

More recently, a combination of a statin simvastatin ) with niacin was found to favorably modify both HDL cholesterol and LDL cholesterol levels and reduce cardiovascular events compared with both placebo therapy and underlying treatment with antioxidants in a cohort of 160 patients with coronary disease (12).
Annals of Internal Medicine  •  2005  |  View Paper
The high-density lipoprotein (HDL)-… Treatment Study showed that simvastatin … niacin (mean daily dose 13 mg and 2.4 g, respectively) halt angiographic atherosclerosis progression and reduce major clinical events … 60% in patients with coronary artery disease (CAD) who have low HDL, in comparison with placebos, over 3 years.
The American journal of cardiology  •  2004  |  View Paper
The protective increase in HDL2 with simvastatin plus niacin was attenuated by concurrent therapy with antioxidants.
The New England journal of medicine  •  2001  |  View Paper
A combination of 40 mg simvastatin with a bile acid sequestrant or a nicotinic acid derivative resulted in a cholesterol lowering of 38% and an LDL lowering of 48% respectively.
Schweizerische medizinische Wochenschrift  •  1991  |  View Paper
Recent studies have shown that the combination of a fixed dose of extended-release niacin plus simvastatin reduces non-HDL-cholesterol, LDL-cholesterol, triglycerides and total cholesterol:HDL-cholesterol ratio by approximately 50% while increasing HDL-cholesterol by 25%.
Expert review of cardiovascular therapy  •  2008  |  View Paper
ER niacin combined with simvastatin provides an additional option for achieving LDL-C … prevention, with greater efficacy in those with triglyceride levels >200 mg/dL. ER niacin … simvastatin 20 mg reduced LDL-C by 6%, non-HDL-C by … HDL-C by 11% compared to simvastatin 20 mg alone.
Vascular health and risk management  •  2009  |  View Paper
Thirty-four patients with coronary artery disease (CAD) receiving simvastatin plus niacin or placebo for both drugs for three years were randomly selected to undergo MRI of carotid arteries.
The International Journal of Cardiovascular Imaging  •  2006  |  View Paper
With a … of simvastatin 40 … and niacin (Niaspan; Kos Pharmaceuticals) 1000 mg daily, the patient’s lipid profile improved, with LDL 78 mg/dL, HDL 43 mg/dL, … triglycerides 60 mg/dL. Follow-up stress testing demonstrated normal myocardial perfusion, and the patient has been asymptomatic for 2 years.
Circulation  •  2004  |  View Paper
We present the first evidence that simvastatin reduces adrenal CA secretion induced by stimulation of nicotinic and AT1-receptors.
Archives of pharmacal research  •  2018  |  View Paper
The additive effect of niacin on top of simvastatin is mostly dependent on its nonHDL-cholesterol-lowering capacities.
PloS one  •  2013  |  View Paper
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