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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Simvastatin
Research Papers that Mention the Interaction
“More recently, a combination of a statin simvastatin ) with niacin was found to favorably modify both HDL cholesterol and LDL cholesterol levels and reduce cardiovascular events compared with both placebo therapy and underlying treatment with antioxidants in a cohort of 160 patients with coronary disease (12).”
A Randomized Trial of a Strategy for Increasing High-Density Lipoprotein Cholesterol Levels: Effects on Progression of Coronary Heart Disease and Clinical Events“The high-density lipoprotein (HDL)-… Treatment Study showed that simvastatin … niacin (mean daily dose 13 mg and 2.4 g, respectively) halt angiographic atherosclerosis progression and reduce major clinical events … 60% in patients with coronary artery disease (CAD) who have low HDL, in comparison with placebos, over 3 years.”
“The protective increase in HDL2 with simvastatin plus niacin was attenuated by concurrent therapy with antioxidants.”
“A combination of 40 mg simvastatin with a bile acid sequestrant or a nicotinic acid derivative resulted in a cholesterol lowering of 38% and an LDL lowering of 48% respectively.”
“Recent studies have shown that the combination of a fixed dose of extended-release niacin plus simvastatin reduces non-HDL-cholesterol, LDL-cholesterol, triglycerides and total cholesterol:HDL-cholesterol ratio by approximately 50% while increasing HDL-cholesterol by 25%.”
“ER niacin combined with simvastatin provides an additional option for achieving LDL-C … prevention, with greater efficacy in those with triglyceride levels >200 mg/dL. ER niacin … simvastatin 20 mg reduced LDL-C by 6%, non-HDL-C by … HDL-C by 11% compared to simvastatin 20 mg alone.”
“Thirty-four patients with coronary artery disease (CAD) receiving simvastatin plus niacin or placebo for both drugs for three years were randomly selected to undergo MRI of carotid arteries.”
“With a … of simvastatin 40 … and niacin (Niaspan; Kos Pharmaceuticals) 1000 mg daily, the patient’s lipid profile improved, with LDL 78 mg/dL, HDL 43 mg/dL, … triglycerides 60 mg/dL. Follow-up stress testing demonstrated normal myocardial perfusion, and the patient has been asymptomatic for 2 years.”
“We present the first evidence that simvastatin reduces adrenal CA secretion induced by stimulation of nicotinic and AT1-receptors.”
Simvastatin reduces adrenal catecholamine secretion evoked by stimulation of cholinergic nicotinic and angiotensinergic AT1 receptors“The additive effect of niacin on top of simvastatin is mostly dependent on its nonHDL-cholesterol-lowering capacities.”
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