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Last Updated: 3 years ago

Possible Interaction: Niacin and Serotonin



Research Papers that Mention the Interaction

Niacin increases plasma PGD2 and serotonin in a rat model of flush.
Journal of Pharmacology and Experimental Therapeutics  •  2008  |  View Paper
5-HT release is modulated by a variety of neuromodulators acting on adrenoreceptors, nicotinic and muscarinic cholinoreceptors and 5-HT3 receptors (Racke et al. 1996).
The Journal of physiology  •  2006  |  View Paper
It is suggested that niacin perhaps facilitates the release of free serotonin and promotes its action at the receptor sites.
Clinica chimica acta; international journal of clinical chemistry  •  1970  |  View Paper
Exogenous ligands such as galanthamine and the neurotransmitter 5-hydroxytryptamine , when applied in submicromolar concentrations with nicotinic agonists, significantly increase the frequency of opening of nicotinic receptor channels and potentiate agonist-activated currents.
Molecular pharmacology  •  1996  |  View Paper
S-zacopride, like renzapride and 5-HT , presynaptically inhibited nicotinic fast excitatory postsynaptic potentials, an effect that can be mediated by 5-HT1P or 5-HT1A receptors.
The American journal of physiology  •  1991  |  View Paper
It is, therefore, suggested that diphasic effect of 5-HT on the nicotinic transmission is due mainly to a modulation of the ACh-release from presynaptic nerve terminals.
Journal of the autonomic nervous system  •  1989  |  View Paper
Thus serotonin , probably acting on 5-HT1A receptors, blocks effectively but indiscriminately all cholinergic facilitations, whether mediated by nicotinic or muscarinic receptors.
Canadian journal of physiology and pharmacology  •  1989  |  View Paper
Fast nicotinic excitatory postsynaptic potentials (EPSPs) and slow EPSPs recorded from S neurons in the myenteric plexus were suppressed by 5-HT , 5-CT, and DPAT; slow EPSPs in myenteric AH neurons were also inhibited by these agonists.
The American journal of physiology  •  1988  |  View Paper
The evoked nicotinic excitatory postsynaptic potential and the adrenergic inhibitory postsynaptic potential were decreased by 5-hydroxytryptamine ; a portion of this inhibition showed desensitization and was blocked by ICS 205-930 as well as by the muscarinic receptor antagonists, atropine and pirenzepine.
Neuroscience  •  1988  |  View Paper
Nicotinic acid , an agent which may decrease cyclic AMP levels, decreased relaxation by serotonin.
Comparative biochemistry and physiology. A, Comparative physiology  •  1972  |  View Paper
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