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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“We hypothesize that salicylic acid causes a concentration‐dependent decrease of total nicotinic acid clearance that results in the saturation (and effective elimination) of the nicotinuric acid conjugation pathway.”
Pharmacokinetics of nicotinic acid – salicylic acid interaction“The results obtained in the present work suggest a mutual influence of NA and SA on their permeation across the skin from an innovative transdermal film.”
Combined patch containing salicylic acid and nicotinamide: role of drug interaction.“S. aureus 79 and 80 were affected synergistically by the combinations of nicotinic acid , or nicotinamide with salicylate.”
The sensitivity of Staphylococcus aureus 79 and 80, and Escherichia coli 95 to sodium salicylate, nicotinaldehyde singly, and in combination with nicotinic acid or nicotinamide.“Along with 2-hydroxynicotinic acid (Ki = 2.3 × … following nonsteroidal anti-inflammatory compounds competed reversibly with nicotinic acid for the enzyme: flufenamic acid (Ki = 4.…), mefenamic acid (Ki = 7.6 × 10−5M), salicylic acid (Ki = 1.6 × 10−4M), phenylbutazone (Ki = 1.…), and indomethacin (Ki = 4.2 × 10−4M).”
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