Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Niacin and S-Adenosylmethionine

supplement:

Niacin

Research Papers that Mention the Interaction

Also plasma NA half-life was significantly reduced (p less than 0.01) by the higher dose of SAMe in respect to placebo and not by the lower dose.
S-adenosyl-L-methionine might therefore prove effective in improving the efficiency of the transport of organic anions such as nicotinic acid (NA) and bilirubin which is impaired in Gilbert's syndrome (GS).
Scandinavian journal of clinical and laboratory investigation  •  1988  |  View Paper
Folate deficiency decreased levels of choline and N-methyl nicotinamine, while dietary supplementation with SAM increased methylation of nicotinamide to generate N-methyl nicotinamide and restored choline levels within brain tissue.
The journal of nutrition, health & aging  •  2008  |  View Paper
SAMe treatment was followed by a significant decrease of basal STB, STB peak and AUC of STB after NA load in EM (p less than 0.01 vs pre-treatment values) while NA half-life was significantly shortened in both groups (p less than 0.001).
Scandinavian journal of clinical and laboratory investigation  •  1990  |  View Paper
Depletion of the hepatic SAM pool has likewise been shown to mediate, at least in part, the hepatotoxic effects of ethanol, methotrexate, and niacinamide.
If niacin does indeed decrease SAM , a likely consequence would be a counterproductive elevation of plasma homocysteine.
Medical hypotheses  •  2000  |  View Paper