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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Also plasma NA half-life was significantly reduced (p less than 0.01) by the higher dose of SAMe in respect to placebo and not by the lower dose.”
“ S-adenosyl-L-methionine might therefore prove effective in improving the efficiency of the transport of organic anions such as nicotinic acid (NA) and bilirubin which is impaired in Gilbert's syndrome (GS).”
Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome.“Folate deficiency decreased levels of choline and N-methyl nicotinamine, while dietary supplementation with SAM increased methylation of nicotinamide to generate N-methyl nicotinamide and restored choline levels within brain tissue.”
“ SAMe treatment was followed by a significant decrease of basal STB, STB peak and AUC of STB after NA load in EM (p less than 0.01 vs pre-treatment values) while NA half-life was significantly shortened in both groups (p less than 0.001).”
“Depletion of the hepatic SAM pool has likewise been shown to mediate, at least in part, the hepatotoxic effects of ethanol, methotrexate, and niacinamide.”
“If niacin does indeed decrease SAM , a likely consequence would be a counterproductive elevation of plasma homocysteine.”
Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy.
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