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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Nicotinamide is an inhibitor of poly ( ADP‐ribose ) polymerase‐1 (PARP‐1) that, through enhancement of nuclear kappa B‐mediated transcription, plays a pivotal role in the expression of inflammatory cytokines, chemokines, adhesion molecules, and inflammatory mediators.”
Nicotinamide: a potential addition to the anti‐psoriatic weaponry“ Nicotinamide inhibits the NAD+-glycohydrolase reaction in the system containing 33 mM phosphate, NAD+ and adenosine and simultaneously it lowers the utilization of ribose.”
“Higher concentrations of nicotinic acid (50 μM) together with adenine and ribose significantly enhanced the total NAD level under aerobic conditions by 77%, ATP by 37%, and AN by 24% during a 24-hr period.”
“However, a high concentration of nicotinamide also impairs the new synthesis of AN from adenine and ribose in the salvage pathway.”
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