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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
supplement:
Resveratrol
Research Papers that Mention the Interaction
“The inhibition of resveratrol was inversed partially by sirtuin 1 (SIRT1) inhibitors ( Nicotinamide , 1-10 mM) (p<0.05).”
Resveratrol suppresses lipoprotein-associated phospholipase A2 expression by reducing oxidative stress in macrophages and animal models.“For the first time, we report the ability of NAM to augment PARP1 activation, induced by RSV , and its associated anti-inflammatory effects mediated through the induction of BCL6 with the concomitant down regulation of COX-2.”
“Strikingly, the combination of RSV with NAM , exerts additive effects on PARP1 activation.”
“Conversely, suppression of SIRT1 activity with nicotinamide inhibited the effect of resveratrol on JNK phosphorylation, leading to restoration of resistance to oxidation-induced apoptosis.”
“Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide , a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs.”
“The Sirt1 inhibitor, nicotinamide (NIC), partially neutralized the effects of RV on the expression of Sirt1 in the DOX‑treated cells and completely abolished the effects of RV on the expression of GRP78 and CHOP.”
“In contrast, pretreatment of cardiomyocytes with an SIRT1 antagonist, nicotinamide , blocked these beneficial effects of resveratrol.”
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.“Treatment with resveratrol promoted the protein expression of SIRT1, but not PGC-1α; instead, resveratrol facilitated PGC-1α translocation from the cytoplasm to the nucleus and up-regulated NRF1 and TFAM, which were blocked by nicotinamide.”
“The effects of Res were blocked by the 5'-adenosine monophosphate-activated protein kinase inhibitor Compound C and the sirtuin 1 inhibitor nicotinamide.”
“The effects of Res were blocked by the 5'-adenosine monophosphate-activated protein kinase inhibitor Compound C and the silencing information regulator T1 inhibitor nicotinamide.”
“Furthermore, the protective effects of RES were arrested by the SIRT1 inhibitor nicotinamide.”
Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes.
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