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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Niacin and Pyrazinamide

supplement:

Niacin

Research Papers that Mention the Interaction

We have recently reported that the antituberculosis drug, pyrazinamide (PZA), caused a significant increase in the conversion ratio of tryptophan to niacin in rats.
Bioscience, biotechnology, and biochemistry  •  2002  |  View Paper
The administration of pyrazinamide significantly increased the metabolites, 3-hydroxyanthranilic acid and beyond, especially quinolinic acid, nicotinamide , N1-methylnicotinamide, and N1-methyl-4-pyridone-3-carboxamide, and therefore significantly increased the conversion ratio of tryptophan to niacin and the blood NAD level.
Bioscience, biotechnology, and biochemistry  •  2001  |  View Paper