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Last Updated: 3 years ago

Possible Interaction: Niacin and Prostaglandin D2



Research Papers that Mention the Interaction

Niacin boosted PGD2 generation in lung tissue, mainly through H-PGDS (hematopoietic PGD2 synthases).
Circulation research  •  2020  |  View Paper
Here, we observed niacin administration‐enhanced PGD2 production in colon tissues in dextran sulfate sodium (DSS)‐challenged mice, and protected mice against DSS or 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitis in D prostanoid receptor 1 (DP1)‐dependent manner.
EMBO molecular medicine  •  2017  |  View Paper
In addition to boosting PGD2, niacin binding to GPR109A activates the entire prostanoid cascade.
Nutrition and cancer  •  2011  |  View Paper
Niacin directly activates both GPR-109A in leukocytes and the heme oxygenase-1 pathway, promoting strong anti-inflammatory and antioxidative effects, as well as induces immediate production of prostaglandin D2 , leading to endothelial vasodilation.
Clinical therapeutics  •  2014  |  View Paper
Niacin was associated with a two- to three-fold increase of thromboxane B2, prostaglandins D2 , and E2.
Thrombosis and haemostasis  •  2010  |  View Paper
Nicotinuric acid, but not nicotinamide , also induced PGD2 secretion.
Atherosclerosis  •  2007  |  View Paper
Niacin has also been shown to interfere with the cyclic AMP (cAMP)/protein kinase A (PKA) pathway and massively stimulate prostaglandin D2 (PGD2) formation.
Biochemical pharmacology  •  2004  |  View Paper
Further, PGD2 has been implicated in the adverse effects of some pharmacologic agents (e.g. nicotinic acid).
Journal of chromatography  •  1993  |  View Paper
In this study we report the finding that ingestion of niacin evokes the release of markedly increased quantities of PGD2 in vivo in humans.
Prostaglandins  •  1989  |  View Paper
We found that niacin increased PGD2 release in macrophages and shifted macrophages to M2 polarization both in vitro and in vivo by activation of DP1 and accelerated inflammation resolution in zymosan-induced peritonitis in mice.
The Journal of Pharmacology and Experimental Therapeutics  •  2017  |  View Paper
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