Possible Interaction: Niacin and Prostaglandin D2

“ Niacin boosted PGD2 generation in lung tissue, mainly through H-PGDS (hematopoietic PGD2 synthases).”

“Here, we observed niacin administration‐enhanced PGD2 production in colon tissues in dextran sulfate sodium (DSS)‐challenged mice, and protected mice against DSS or 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitis in D prostanoid receptor 1 (DP1)‐dependent manner.”

“In addition to boosting PGD2, niacin binding to GPR109A activates the entire prostanoid cascade.”

“ Niacin directly activates both GPR-109A in leukocytes and the heme oxygenase-1 pathway, promoting strong anti-inflammatory and antioxidative effects, as well as induces immediate production of prostaglandin D2 , leading to endothelial vasodilation.”

“ Niacin was associated with a two- to three-fold increase of thromboxane B2, prostaglandins D2 , and E2.”

“Nicotinuric acid, but not nicotinamide , also induced PGD2 secretion.”

“ Niacin has also been shown to interfere with the cyclic AMP (cAMP)/protein kinase A (PKA) pathway and massively stimulate prostaglandin D2 (PGD2) formation.”

“Further, PGD2 has been implicated in the adverse effects of some pharmacologic agents (e.g. nicotinic acid).”

“In this study we report the finding that ingestion of niacin evokes the release of markedly increased quantities of PGD2 in vivo in humans.”

“We found that niacin increased PGD2 release in macrophages and shifted macrophages to M2 polarization both in vitro and in vivo by activation of DP1 and accelerated inflammation resolution in zymosan-induced peritonitis in mice.”