Possible Interaction: Niacin and Propranolol

“In a series that utilized doses of 40 and 80 mg of propranolol HC1 taken orally 30 min prior to the ingestion of 500 or 1000 mg of niacin , a progressive increase in the onset of the niacin flush was observed.”

“The nicotinic agonists acetylcholine, nicotine, and its nitrosated carcinogenic derivative NNK induced the phosphorylation of CREB, ERK, Src, and AKT and these responses were inhibited by propranolol.”

“Both 1,1-dimethyl-4-phenylpiperazinium iodide and nicotine relaxed muscle strips, possibly by releasing an adrenergic neurotransmitter which, because the responses to nicotinic receptor-stimulation were blocked by propranolol , stimulated beta-adrenergic inhibitory receptors.”

“Verapamil (Ver), MnCl2, nifedipine (Nif), and propranolol (Pro) depressed markedly the positive inotropic effect induced by Nic in a noncompetitive manner.”

“This paper describes an inhibitory effect of propranolol on insulin secretion in rats with pancreatic islet cell tumors which have been induced by streptozotocin (65 mg/kg body weight) and nicotinamide (500 mg/kg).”

“The stimulatory effect was strongly inhibited by the beta-adrenergic blocker propranolol and by the antilipolytic agent nicotinic acid.”

“A similar inhibitory effect of propranolol and nicotinic acid used in combination was noted in a sustained reversal of norepinephrine-induced elevations of serum glycerol and plasma free fatty acids.”

“The effects of small doses of propranolol and nicotinic acid used in combination on the inhibition of norepinephrine-induced elevations of serum triglyceride may be explained by their additive inhibition of plasma free fatty acid mobilization.”

“The synergistic action of propranolol and nicotinic acid in the suppression of free fatty acid mobilization may be explained by the action of these two agents on the inhibition of the adenyl cyclase system of the adipose tissue cell.”