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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Niacin and Primidone



Research Papers that Mention the Interaction

In mice, 200 mg per kilogram of nicotinamide increased the half-life of primidone by 47.6%, and the conversion to phenobarbital and phenylethylmalonamide was decreased by 32.4% and 14.5%, respectively.
Nicotinamide also decreased the conversion of primidone to phenobarbital in patients.
The data demonstrate that nicotinamide inhibits metabolism of primidone in mice and metabolism of primidone and carbamazepine in humans.
Neurology  •  1982  |  View Paper
Intentional inhibition of PRM metabolism by nicotinamide serves as an example of attempts to utilize an interaction for improved therapeutic effect.
Epilepsia  •  1984  |  View Paper