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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Niacin
drug:
Phenylbutazone
Research Papers that Mention the Interaction
“The flush induced in guinea-pigs by oral nicotinic acid was reduced by the previous administration of phenylbutazone.”
EFFECTS OF ANTI-RHEUMATIC COMPOUNDS AND PYRIDINE DERIVATIVES ON THE CUTANEOUS RESPONSE TO THURFYL NICOTINATE IN THE GUINEA-PIG.“Along with 2-hydroxynicotinic acid (Ki = 2.3 × … following nonsteroidal anti-inflammatory compounds competed reversibly with nicotinic acid for the enzyme: flufenamic acid (Ki = 4.6 × 10−5M), mefenamic ….6 × 10−5M), salicylic acid (Ki = 1.6 × 10−4M), phenylbutazone (Ki = 1.6 × 10−4M), … = 4.2 × 10−4M).”
Inhibition of nicotinate phosphoribosyl transferase by nonsteroidal anti-inflammatory drugs: a possible mechanism of action.
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