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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Niacin and Phenobarbital



Research Papers that Mention the Interaction

Numerical values of properties for nicotinic acid showed very high correlation with the values from dihydropyridine, barbital, metharbital, phenobarbital , methohexital, 4-aminohex-5-enoic acid, and (4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone.
Receptors & channels  •  2004  |  View Paper
Nicotinamide also decreased the conversion of primidone to phenobarbital in patients.
Neurology  •  1982  |  View Paper
PB was found to elevate nicotinamide N-methyltransferase activity 3- to 4-fold in mice and rats and to attenuate levels of NAD+, NADP+, NADH, and NADPH in both species (20–40%), due to the enhanced excretion of (N-methyl)nicotinamide.
Journal of Biological Chemistry  •  2008  |  View Paper
Administration of nicotinamide in combination with ziksorin or phenobarbital enhanced the enzyme-inducing effects of the latter.
Farmakologiia i toksikologiia  •  1988  |  View Paper
At doses that were ineffective by themselves (0.01 effective dose) nicotinamide potentiated the anticonvulsant activity of phenobarbital against bicuculline and pentylenetetrazol, but the toxicity was not potentiated and therefore the therapeutic index of phenobarbital was improved by nicotinamide.
Epilepsia  •  1983  |  View Paper
It was suggested that PB and PhB had much greater blocking potency for the receptor activities of " nicotinic type " than that for the "muscarinic type".
Nihon seirigaku zasshi. Journal of the Physiological Society of Japan  •  1981  |  View Paper