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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Niacin
drug:
Phenobarbital
Research Papers that Mention the Interaction
“Numerical values of properties for nicotinic acid showed very high correlation with the values from dihydropyridine, barbital, metharbital, phenobarbital , methohexital, 4-aminohex-5-enoic acid, and (4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone.”
Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques.“ Nicotinamide also decreased the conversion of primidone to phenobarbital in patients.”
“ PB was found to elevate nicotinamide N-methyltransferase activity 3- to 4-fold in mice and rats and to attenuate levels of NAD+, NADP+, NADH, and NADPH in both species (20–40%), due to the enhanced excretion of (N-methyl)nicotinamide.”
Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems*“Administration of nicotinamide in combination with ziksorin or phenobarbital enhanced the enzyme-inducing effects of the latter.”
“At doses that were ineffective by themselves (0.01 effective dose) nicotinamide potentiated the anticonvulsant activity of phenobarbital against bicuculline and pentylenetetrazol, but the toxicity was not potentiated and therefore the therapeutic index of phenobarbital was improved by nicotinamide.”
“It was suggested that PB and PhB had much greater blocking potency for the receptor activities of " nicotinic type " than that for the "muscarinic type".”
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