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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Pentoxifylline
Research Papers that Mention the Interaction
“Patients received single oral doses of nicotinamide 40 mgkg-1 and pentoxifylline 1200 mg 2h before a 10-min period of carbogen gas breathing, corresponding to peak plasma concentrations of these drugs.”
The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen.“The median tumor pO2 increased from a mean +/- S.E.M. of 4.1 +/- 1.1 mm Hg in saline-treated control mice to … Hg 15 min after NA, 7.6 +/- 1.4 mm Hg 60 min after PTX, and 6.7 +/- 1.1 mm Hg after NA … PTX ….”
Effect of nicotinamide and pentoxifylline on normal tissue and FSA tumor oxygenation.“We hypothesized that the combination of pentoxifylline (PTX) and nicotinamide (NA) can reduce the radioresistance of FSaII murine fibrosarcoma by improving oxygenation of the hypoxic tumour cells.”
“However, PENTO + NA slightly increased the bone marrow death as demonstrated by the decrease in LD50(30) from 5.5 Gy to 5.2 Gy.”
“The combination of PENTO and NA further delayed the growth of tumors.”
“When combined with NA , the enhancing effects of PENTO was enhanced especially at lower radiation doses, whereas that of SR was decreased.”
Radiation enhancing effect of pentoxifylline.
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