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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Niacin
drug:
Penicillins
Research Papers that Mention the Interaction
“Acute experiments … that nicotinamide (100-500 mg/kg) injected intravenously suppresses the epileptic activity in solitary … cortex by application for several seconds of a 0.5% solution of penicillin as well as in the complex of foci produced by … 0.1--3% solution of strychnine to various cortical zones.”
Further study of the antiepileptic properties of nicotinamide“Intraperitoneal injection of nicotinamide to rats inhibits epileptic activity induced by penicillin application in the animals' brain cortex.”
“The nicotinamide methochloride output was decreased by the second course of penicillin to a deficiency level, and severe deficiency symptoms were experienced.”
“The nicotinamide status of patients treated orally with penicillin should therefore be watched, and if necessary nicotinamide should be given parenterally.”
Work of Government Lymph Establishment, 1898 to 1946“Summary High concentrations of nicotinamide exert a synergistic effect upon penicillin inhibition of Staphylococcus aureus.”
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