Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Niacin and Nitric Oxide



Research Papers that Mention the Interaction

Nicotinamide inhibits poly (ADP-ribose) polymerase and reduces nitric oxide accumulation in the NOD pancreas and protect beta cells against radical-induced necrosis.
Diabetes research and clinical practice  •  2004  |  View Paper
Hence, NIC could scavenge O2- and allow NO to inhibit the enzyme.
The NO donor SIN-1 inhibits in a concentration-dependent manner iNOS activity, and the effect is potentiated by NIC.
Endocrinology  •  1996  |  View Paper
NA dose- and time-dependently inhibited and delayed IL-1 β-induced islet NO production.
Therefore, we studied whether NA prevented IL-1 β-induced islet NO production, measured as nitrite release from isolated rat islets, and, if so, whether this action was associated with prevention of IL-1 β-mediated inhibition of insulin release.
These results suggest a novel mechanism for NA-mediated protection of IL-1–induced P-cell damage via an inhibitory effect of NA on the formation of NO.
Diabetes  •  1994  |  View Paper
Nitric oxide accumulation, induced by IFN-γ/TNF-α, was inhibited by nicotinic acid and 3-hydroxy-butyrate.
Annals of clinical and laboratory science  •  2015  |  View Paper
Additionally, nicotinamide significantly attenuated phosphorylation of nuclear factor-&kgr;B's inhibitory protein, nuclear factor-&kgr;B translocation and binding activity, and the synthesis of inducible nitric oxide in the ischemic brain (p < .05, respectively).
Critical care medicine  •  2012  |  View Paper
The nicotinamide protection of beta-cells may be facilitated via inhibition of apoptosis and nitric oxide generation.
Iranian journal of allergy, asthma, and immunology  •  2009  |  View Paper
Results:It was shown that at non-cytotoxic concentrations, NA inhibits the production of a variety of pro-inflammatory agents, such as tumor necrosis factor α, interleukin 6, NO , PGE2, and the generation of ROS.
Archivum Immunologiae et Therapiae Experimentalis  •  2008  |  View Paper
NA potentiates the effect of 131I by increasing eNOS, which would in turn stimulate NO production, increasing thyroid blood flow and tissue damage via organic peroxides.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2006  |  View Paper
We have previously demonstrated that this regulatory phenomenon is partly modulated by nitric oxide which exerts a dual effect: facilitation or inhibition of the nicotinic activation.
Neuroscience  •  2003  |  View Paper
Nic treatment increased NO to 13.88 +/- 2.5 nmol/l and decreased MDA to 3.54 +/- 0.34 ng/mg protein (P = 0.005).
American journal of physiology. Heart and circulatory physiology  •  2002  |  View Paper
Show More