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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Niacin
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ Nicotinamide inhibits poly (ADP-ribose) polymerase and reduces nitric oxide accumulation in the NOD pancreas and protect beta cells against radical-induced necrosis.”
Prevention of type 1 diabetes: from the view point of beta cell damage.“Hence, NIC could scavenge O2- and allow NO to inhibit the enzyme.”
“The NO donor SIN-1 inhibits in a concentration-dependent manner iNOS activity, and the effect is potentiated by NIC.”
“ NA dose- and time-dependently inhibited and delayed IL-1 β-induced islet NO production.”
“Therefore, we studied whether NA prevented IL-1 β-induced islet NO production, measured as nitrite release from isolated rat islets, and, if so, whether this action was associated with prevention of IL-1 β-mediated inhibition of insulin release.”
“These results suggest a novel mechanism for NA-mediated protection of IL-1–induced P-cell damage via an inhibitory effect of NA on the formation of NO.”
“ Nitric oxide accumulation, induced by IFN-γ/TNF-α, was inhibited by nicotinic acid and 3-hydroxy-butyrate.”
GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.“Additionally, nicotinamide significantly attenuated phosphorylation of nuclear factor-&kgr;B's inhibitory protein, nuclear factor-&kgr;B translocation and binding activity, and the synthesis of inducible nitric oxide in the ischemic brain (p < .05, respectively).”
“The nicotinamide protection of beta-cells may be facilitated via inhibition of apoptosis and nitric oxide generation.”
“Results:It was shown that at non-cytotoxic concentrations, NA inhibits the production of a variety of pro-inflammatory agents, such as tumor necrosis factor α, interleukin 6, NO , PGE2, and the generation of ROS.”
“ NA potentiates the effect of 131I by increasing eNOS, which would in turn stimulate NO production, increasing thyroid blood flow and tissue damage via organic peroxides.”
“We have previously demonstrated that this regulatory phenomenon is partly modulated by nitric oxide which exerts a dual effect: facilitation or inhibition of the nicotinic activation.”
“ Nic treatment increased NO to 13.88 +/- 2.5 nmol/l and decreased MDA to 3.54 +/- 0.34 ng/mg protein (P = 0.005).”
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