Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 months ago

Possible Interaction: Niacin and Nikethamide

supplement:

Niacin

Research Papers that Mention the Interaction

NicA treatment resulted in an approximately 2-fold higher concentration of MNA and its metabolites in urine and a 4-fold higher nicotinamide/MNA ratio in plasma, compared with MNA treatment.
The Journal of pharmacology and experimental therapeutics  •  2016  |  View Paper
Co-treatment of astrocytes with nicotinamide and N-methylnicotinamide resulted in a decrease in PAR accumulation and absolute prevention of cell death.
Life sciences  •  2010  |  View Paper
When combined with NA or several chemically-unrelated inducers of hemoglobin synthesis in cultured MELCs, 1-MN reduced the globin mRNA levels and heme accumulation by 40-80%.
Toxicology in vitro : an international journal published in association with BIBRA  •  2007  |  View Paper
Abstract 1-Methylnicotinamide, a direct methylation product of nicotinamide, stimulates the DNA synthesis and proliferation of rat liver cells (RLC) in culture at concentrations higher than 20 μM. The effect of nicotinamide , which is a potent inhibitor of DNA synthesis and proliferation, is counteracted by 1-methylnicotinamide.
The intracellular NAD concentration decreases within 2 h under 1-methylnicotinamide , whereas it increases in the presence of nicotinamide.
Biochemical and biophysical research communications  •  1982  |  View Paper
Urinary excretion of nicotinic acid and N-methylnicotinamide was increased significantly by adding nicotinic acid to the diet but was not affected by adding L-leucine at the 5% level.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  1979  |  View Paper
Nicotinamide induced three- to four-fold increases in hepatic NAD concentration even in the presence of 5-methylnicotinamide or ethionine, whereas 5-methylnicotinamide or ethionine alone did not cause marked changes in hepatic NAD concentration.
The Biochemical journal  •  1969  |  View Paper