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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Niacin
drug:
Muscarinic Agonists
Research Papers that Mention the Interaction
“The resultant clinical picture is of hyperstimulation of both the nicotinic and muscarinic cholinergic system , which, if not promptly treated, leads to severe muscle paralysis, cardiac brady-asystole, hypersecretion from secretory glands, respiratory failure, seizures, coma and death.”
Pathophysiological and clinical aspects of combat anticholinesterase poisoning.“These findings demonstrate the safety and feasibility of differential and combined blockade of nicotinic and muscarinic cholinergic blockade in human subjects.”
“In conclusion, whereas both nicotinic and muscarinic cholinergic antagonists disrupt performance in the attentional task, the increase in response latencies entails that correct responding becomes more dependent on the working memory processes and thus compromises conclusions as to a selective disruption of attention.”
Differential roles for nicotinic and muscarinic cholinergic receptors in sustained visuo-spatial attention? A study using a 5-arm maze protocol in mice“In addition to their direct effects on the [Ca2+]i, muscarinic agonists also reduced the rise in [Ca2+]i induced by a nicotinic agonist.”
“The injection of muscarinic agonists , as well as that of nicotinic antagonists, provoked the appearance of a naso-temporal (N-T) component, the slow phase velocity gain then being strongly and significantly increased.”
“Oxotremorine and other naturally occurring muscarinic agonists are also nicotinic agonists.”
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