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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Niacin and Muscarinic Agonists

Research Papers that Mention the Interaction

The resultant clinical picture is of hyperstimulation of both the nicotinic and muscarinic cholinergic system , which, if not promptly treated, leads to severe muscle paralysis, cardiac brady-asystole, hypersecretion from secretory glands, respiratory failure, seizures, coma and death.
British medical bulletin  •  2004  |  View Paper
These findings demonstrate the safety and feasibility of differential and combined blockade of nicotinic and muscarinic cholinergic blockade in human subjects.
Neurobiology of Aging  •  1992  |  View Paper
In conclusion, whereas both nicotinic and muscarinic cholinergic antagonists disrupt performance in the attentional task, the increase in response latencies entails that correct responding becomes more dependent on the working memory processes and thus compromises conclusions as to a selective disruption of attention.
Behavioural Brain Research  •  2002  |  View Paper
In addition to their direct effects on the [Ca2+]i, muscarinic agonists also reduced the rise in [Ca2+]i induced by a nicotinic agonist.
The American journal of physiology  •  1995  |  View Paper
The injection of muscarinic agonists , as well as that of nicotinic antagonists, provoked the appearance of a naso-temporal (N-T) component, the slow phase velocity gain then being strongly and significantly increased.
Vision Research  •  1992  |  View Paper
Oxotremorine and other naturally occurring muscarinic agonists are also nicotinic agonists.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1991  |  View Paper