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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Niacin
drug:
Laropiprant
Research Papers that Mention the Interaction
“In the light of the results of HPS2-THRIVE study, we may hypothesize that the addition of laropiprant to niacin might be responsible for these negative effects.”
Detrimental effects of niacin/laropiprant on microvascular reactivity and red cell deformability in patients with elevated lipoprotein(a) levels“ Laropiprant (LRPT) reduces flushing associated with niacin.”
“ Laropiprant , an antagonist of the PGD2 receptor, DP1, is effective in reducing the flushing symptoms associated with extended‐release (ER) niacin and thereby improves the tolerability of niacin therapy for dyslipidemia.”
“Lastly, laropiprant , an antagonist of the DP1 receptor of prostaglandin D2, is used in combination with niacin to suppress the niacin-induced vasodilation.9 Figure 1 Major pathways of arachidonic acid metabolism.”
“The flushing associated with niacin which has previously affected patient compliance can now be significantly blocked with laropiprant (LRPT).”
“The favorable safety profile supports the use of LRP to achieve higher therapeutic dosing of niacin.”
“Therefore, it is time to collate available information to assess the safety and tolerability of combining niacin with LRP.”
“DP1 receptor antagonist laropiprant ) attenuates the niacin flush in animals and humans.”
“In HPS2THRIVE, a combination of niacin with the prostaglandin receptor blocker laropiprant did not show any clinical benefit [7] .”
“AIM Cutaneous flushing with niacin varies between individuals and is substantially reduced by concomitant laropiprant.”
“ Niacin commonly causes cutaneous flushing, which is partially alleviated by laropiprant , a selective antagonist of prostaglandin D2 at the DP1 receptor.”
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