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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Niacin and Fenofibrate

supplement:

Niacin

Research Papers that Mention the Interaction

The combination of fenofibrate + nicotinic acid also appears to have a beneficial effect on lipoproteins.
Cardiology  •  1989  |  View Paper
Fenofibric acid led to a +23% (CI +10 to +36, p = 0.001) increase in PCSK9; the addition of niacin resulted in a subsequent -17% decrease (CI -19 to -5, p = 0.004).
The American journal of cardiology  •  2015  |  View Paper
However, niacin worsened the parameters of glycemic control, whereas fenofibrate improved them.
Atherosclerosis  •  2010  |  View Paper
A drug interaction between concomitantly administered single doses of IDD-P fenofibrate and ER niacin could not be ruled out.
The mean C(max), AUC from the time of administration to the last quantifiable concentration (AUC(0-t)), and AUC from the time … fenofibrate alone; and the mean C(max), AUC(0-t), and AUC(0-infinity) were 12%, 6%, and 5% lower, respectively, with IDD-P fenofibrate … niacin ….
Clinical therapeutics  •  2006  |  View Paper
Although monotherapy with cerivastatin is well tolerated and has a low frequency of adverse events, the combination with nicotinic acid (i.e., niacin) or a fibric-acid derivative (i.e., gemfibrozil, fenofibrate ) may result in severe skeletal muscle toxicity and rhabdomyolysis.
The Annals of pharmacotherapy  •  2001  |  View Paper
Niacin showed a potential atheroprotective effects suggesting possible co-administration with fenofibrate with a potential for development of fixed dose combination.
Pharmaceutical development and technology  •  2019  |  View Paper