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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Niacin
Research Papers that Mention the Interaction
“ResultsThere were small (mean ≤35%) increases in drug exposure for all analytes after coadministration of ER niacin and ezetimibe/simvastatin 10 mg/20 mg.”
“The AUC(0–24) (area under the plasma concentration–time curve from time zero to 24 h after dosing) …, simvastatin acid, and nicotinuric acid were 126, 135 and 119%.ConclusionThere is a small pharmacokinetic drug interaction between ER niacin … ezetimibe/simvastatin and although this is … the niacin titration period.”
Assessment of potential pharmacokinetic interactions of ezetimibe/simvastatin and extended-release niacin tablets in healthy subjects“ E/S plus niacin provided a broad, lipid-altering therapeutic option for these patients, even in the presence of diabetes with glucose monitoring.”
“The anticipated niacin-associated flushing led to a greater rate of study discontinuations with the E/S plus niacin regimen than with E/S alone (0.7%, p <0.001).”
“The occurrence of new-onset diabetes was 3.1% for the E/S and 4.9% for the E/S plus niacin group.”
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