Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Niacin and Epoprostenol

supplement:

Niacin

Research Papers that Mention the Interaction

The results indicate that nicotinic acid initially increases prostacyclin production in hyperlipidaemic women and that this increase is abolished during continued treatment.
The Lancet  •  1983  |  View Paper
In cells treated with adenosine deaminase (0.5 U/ml) or with theophylline (0.5 mM), PGI2 (40 nM) inhibited the lipolytic effect of norepinephrine (5 microM) and nicotinic acid acted synergistically with PGI2 at this level.
These results indicate that the antilipolytic action of nicotinic acid is influenced by endogenous adenosine and is increased by PGI2.
Pharmacological research communications  •  1987  |  View Paper