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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Niacin and Duloxetine

supplement:

Niacin

Research Papers that Mention the Interaction

Of interest was that in cell lines expressing human α7, α3β4, and α4β2 nAChRs, duloxetine blocked nicotinic currents with IC50 values of 0.1, 0.56, and 0.85 µM, respectively.
We have found that duloxetine fully blocked the acetylcholine (ACh)-elicited nicotinic currents in BCCs with an IC50 of 0.86 µM. Such blockade seemed to be noncompetitive, voltage dependent, and partially use dependent.
The Journal of Pharmacology and Experimental Therapeutics  •  2018  |  View Paper