“Enhanced sister chromatid exchange (SCE) levels and cell division delays were observed when cultured human lymphocytes treated with carboplatin (cPt) were exposed to niacin.”
“ Niacin increased the survival time of the EAT-bearing mice treated with cPt and markedly reduced the ascitic volume.”
“Therefore the in vivo antitumor effect of cPt in conjunction with niacin appears to correlate well with the in vitro or in vivo synergistic effects on cytogenetic damage caused by the combined cPt plus Niacin treatment upon human lymphocytes or EAT cells, respectively.”