Possible Interaction: Niacin and Calcium Supplement

“… niacin and niacinamide significantly decreased serum phosphorus levels [weight mean difference (…) −1.19 to −0.57] as well as the calcium × phosphorus product (Ca × P) (WMD −9.15; 95 % CI −13.23 to −5.08), …) levels (WMD 9.30; 95 % CI 5.86–12.74) in renal dialysis patients.”

“Of the 19 micronutrients investigated, the mean daily intake of eight calcium , iron, zinc, vitamin A, riboflavin, nicotinic acid , pantothenic acid and biotin) fell below the recommended dietary allowance (RDA) at both interceptions.”

“Treatment with 0.125 mg/ml nicotinamide 48 hours after UVA exposure also significantly inhibited the cell proliferation; 1.25 mg/ml nicotinamide increased calcium concentration in cells; 0.250 mg/ml nicotinamide increased the activities of Na+-K+, Ca2+-ATP enzymes in melanocytes (P < 0.05).”

“ NA increased Ca2+ , glutamate, nitric oxide and reactive oxygen species (ROS) levels in PC12 cells and increased RVLM ROS levels.”

“The alteration in the calcium gradient significantly decreased the permeation rate of a hydrophilic drug, such as nicotinic acid.”

“In addition, beta-escin (0.02%) permeabilisation and Ca2+ (2.5 mM)-mediated constriction was also significantly attenuated by nicotinamide (P < 0.0001).”

“These results support the idea that nicotinic agonists generate an alternative second messenger in addition to the rise in free calcium.”

“ Nicotinamide improved the A-V conduction depressed by low Ca++, but aggravated the A-V conduction depressed by high Ca++.”

“Injection of NiAm elicited a marked increase in UPiV, but no change in excretions of creatinine or K+, or in urine flow; excretion of Na+ and Ca declined.”

“There were linear and quadratic increases in Ca and P contents with the NA supplementation (P < 0.05).”