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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Niacin
drug:
Atorvastatin
Research Papers that Mention the Interaction
“During the next … low-dose atorvastatin with … of niacin to 2 g/day resulted in an 88% decrease in Lp(a) to 18 mg/dL. There are several important … addressed within the framework of the most recent perspectives on the use of niacin in the treatment of lipid disorders.”
Variance in niacin response in individuals with elevated lipoprotein(a).“A combination of atorvastatin and niacin may provide more complete normalization of the lipid profile and increased cardiovascular benefits.”
“Larger lipid studies as well as studies evaluating cardiovascular outcomes during atorvastatin plus niacin treatment are warranted.”
“Overall, the studies were small but indicated that atorvastatin in combination with niacin was efficacious in normalizing lipid parameters.”
“Benzoic acid competitively inhibitedatorvastatin uptake with a Ki of 14 mM. Similarly, benzoic acid nicotinic acid , and acetic acid significantly, inhibited the A-to-Bpermeability of atorvastatin by 71%, 21%, and 66%, respectively.”
“In addition, atorvastatin uptake was significantly inhibited bybenzoic acid, nicotinic acid , and acetic acid each at 20 mM (65%,14%, and 40%, respectively).”
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